Mouse Models for Atopic Dermatitis Developed in Japan
نویسندگان
چکیده
Hiromichi Yonekawa1, Toyoyuki Takada2, Hiroshi Shitara1, Choji Taya1, Yoshibumi Matsushima3, Kunie Matsuoka4 and Yoshiaki Kikkawa4 1Center for Basic Technology Research Tokyo Metropolitan Institute of Medical Science, Tokyo 2Mammalian Genetics Laboratory, National Institute of Genetics, Mishima 3Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama 4Mammalian Genetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Japan
منابع مشابه
Pathogenesis of Atopic Dermatitis: Current Paradigm
Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...
متن کاملComparison of diagnostic criteria for Atopic dermatitis in epidemiological studies
Atopic dermatitis is one of the commonest childhood diseases. Large variations in the prevalence of the disease have been observed in different studies. This variation in the prevalence may be not only from genetic and environmental factors but also from methodology of estimating prevalence of the disease. In this study, Hanifin and UKWP criteria have been used in determining prevalence of the ...
متن کاملRecent findings in mouse models for human atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disease, with its major clinical feature being persistent itch sensation in the skin. There are extremely few animal models to reproduce the complicated condition of a patient with AD; therefore researchers have been confronted with some difficulties in pathologic analysis and drug development for AD. Although various models have been propos...
متن کاملSpecific IgE to Common Food Allergens in Children with Atopic Dermatitis
Background: Atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. Although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about common food allergens in Iranian children with atopic dermatitis. Objectives: This study was des...
متن کاملPrevalence of Atopic Eczema in Infants under Two Years Referring to the Vaccination Ward of the Hazrat Rasoul Akram Hospital, Tehran, Iran
Background & Aims: Atopic dermatitis is a common allergic disease recognized as a threat to public health. Atopic dermatitis is often observed in people with individual or family history of allergic diseases. Due to the importance of this disease and its early diagnosis, and the very limited number of studies on this topic, the current study was performed on the prevalence of atopic dermatitis ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012